Whole plant based treatment of hypercholesterolemia with Crataegus laevigata in a zebrafish model

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Whole plant based treatment of hypercholesterolemia with Crataegus laevigata in a zebrafish model

BACKGROUND Consumers are increasingly turning to plant-based complementary and alternative medicines to treat hypercholesterolemia. Many of these treatments are untested and their efficacy is unknown. This multitude of potential remedies necessitates a model system amenable to testing large numbers of organisms that maintains similarity to humans in both mode of drug administration and overall ...

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Treatment of hypercholesterolemia: screening of Solanum macrocarpon Linn (Solanaceae) as a medicinal plant in Benin

Objective: Hypercholesterolemia is the greatest risk factor for cardiovascular diseases. The present study is conducted to evaluate the lipid lowering activity of leaves and fruits of Solanum macrocarpon, a vegetable, on Wistar rats experimentally rendered hypercholesterolemic by Triton X-100. Materials and Methods: The leaves and fruits were administered (p.o.) for 7 days to rats at doses of 4...

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treatment of hypercholesterolemia: screening of solanum macrocarpon linn (solanaceae) as a medicinal plant in benin

objective: hypercholesterolemia is the greatest risk factor for cardiovascular diseases. the present study is conducted to evaluate the lipid lowering activity of leaves and fruits of solanum macrocarpon, a vegetable, on wistar rats experimentally rendered hypercholesterolemic by triton x-100. materials and methods: the leaves and fruits were administered (p.o.) for 7 days to rats at doses of 4...

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Automated In Vivo Platform for the Discovery of Functional Food Treatments of Hypercholesterolemia

The zebrafish is becoming an increasingly popular model system for both automated drug discovery and investigating hypercholesterolemia. Here we combine these aspects and for the first time develop an automated high-content confocal assay for treatments of hypercholesterolemia. We also create two algorithms for automated analysis of cardiodynamic data acquired by high-speed confocal microscopy....

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ژورنال

عنوان ژورنال: BMC Complementary and Alternative Medicine

سال: 2012

ISSN: 1472-6882

DOI: 10.1186/1472-6882-12-105